1,2-Dichloroethane → 4-(4-fluoro-3-methylphenyl)-4-methoxy-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

HRID 941804Notes

Reaction equation

HRID 941804 reaction equation
[CH2:40]([Cl:41])[CH2:42][Cl:43].[Cl:45][CH2:46][Cl:47].[ClH:44].[F:24][c:25]1[c:26]([CH3:39])[cH:27][c:28]([CH:31]([CH2:32][CH2:33][C:34](=[O:35])[OH:36])[O:37][CH3:38])[cH:29][cH:30]1.[Na+:23].[O-:19][C:20]([OH:21])=[O:22].[O:1]1[CH:2]([O:7][NH2:8])[CH2:3][CH2:4][CH2:5][CH2:6]1.[OH:9][n:10]1[c:11]2[c:12]([cH:13][cH:14][cH:15][cH:16]2)[n:17][n:18]1>>[O:1]1[CH:2]([O:7][NH:8][C:34]([CH2:33][CH2:32][CH:31]([c:28]2[cH:27][c:26]([CH3:39])[c:25]([F:24])[cH:30][cH:29]2)[O:37][CH3:38])=[O:35])[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 757711-HydroxybenzotriazoleHCID 5142091O-(Tetrahydropyran-2-yl)hydroxylamineHCID 667544854-(4-Fluoro-3-methylphenyl)-4-methoxybutanoic acid

Product 1

HCID 723283874-(4-fluoro-3-methylphenyl)-4-methoxy-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Sources & evidence

ORD record
ord-97828c933b864326816db3ebf7d137eb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…