Hydrochloric Acid → Tert-butyl 3-[[3-[(4-methylsulfonylphenyl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]-4-phenylpyrrolidine-1-carboxylate

HRID 941884Notes

Reaction equation

HRID 941884 reaction equation
[C:32]([CH3:33])([CH3:34])([CH3:35])[O:36][C:37](=[O:38])[N:39]1[CH2:40][CH:41]([CH:50]=[O:51])[CH:42]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[CH2:43]1.[C:52]([O:53][BH-:54]([O:55][C:56](=[O:57])[CH3:58])[O:59][C:60](=[O:61])[CH3:62])(=[O:63])[CH3:64].[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([CH2:10][N:11]2[C:12](=[O:22])[NH:13][C:14]3([C:15]2=[O:16])[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]3)[cH:23][cH:24]1.[Cl:66][CH2:67][Cl:68].[ClH:1].[Na+:65]>>[CH3:2][S:3](=[O:4])(=[O:5])[c:6]1[cH:7][cH:8][c:9]([CH2:10][N:11]2[C:12](=[O:22])[NH:13][C:14]3([C:15]2=[O:16])[CH2:17][CH2:18][N:19]([CH2:50][CH:41]2[CH2:40][N:39]([C:37]([O:36][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:38])[CH2:43][CH:42]2[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[CH2:20][CH2:21]3)[cH:23][cH:24]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 6344DichloromethaneHCID 8471TriethylamineHCID 2724942TriacetoxyborohydrideHCID 686263333-[(4-Methylsulfonylphenyl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dioneHCID 724802973-(RS)-formyl-4-(SR)-phenylpyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 73034699Tert-butyl 3-[[3-[(4-methylsulfonylphenyl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]-4-phenylpyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-478b5418fbcf4719b5771e25113100d9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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