Dimethylformamide → 6-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide

HRID 942025Notes

Reaction equation

HRID 942025 reaction equation
[CH:23]([N:24]([CH2:25][CH3:26])[CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[Cl:10])[n:5][cH:6][n:7]1.[Cl:32][CH2:33][Cl:34].[NH2:11][c:12]1[c:13]([CH3:22])[cH:14][c:15]([S:18](=[O:19])(=[O:20])[NH2:21])[cH:16][cH:17]1.[O:35]=[CH:36][N:37]([CH3:38])[CH3:39]>>[Cl:1][c:2]1[cH:3][c:4]([C:8](=[O:9])[NH:11][c:12]2[c:13]([CH3:22])[cH:14][c:15]([S:18](=[O:19])(=[O:20])[NH2:21])[cH:16][cH:17]2)[n:5][cH:6][n:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 1430374-Amino-3-methylbenzene-1-sulfonamideHCID 184220986-Chloropyrimidine-4-carbonyl chloride

Product 1

HCID 594470566-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide

Sources & evidence

ORD record
ord-5f7e473a5da4475d89d93af5b85bb2db
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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