Dimethylformamide → phenyl N-[4-(3-fluoro-4-{[1-(phenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]-N-phenoxycarbonylcarbamate

HRID 942338Notes

Reaction equation

HRID 942338 reaction equation
[CH3:50][CH2:51][N:52]([CH2:53][CH3:54])[CH2:55][CH3:56].[CH3:84][N:85]([CH3:86])[CH:87]=[O:88].[P-:57]([F:58])([F:59])([F:60])([F:61])([F:62])[F:63].[c:1]1([O:7][C:8]([N:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[c:19]2[n:20][cH:21][cH:22][c:23]([O:25][c:26]3[cH:27][c:28]([F:33])[c:29]([NH2:32])[cH:30][cH:31]3)[cH:24]2)=[O:34])[cH:2][cH:3][cH:4][cH:5][cH:6]1.[c:35]1([NH:41][C:42](=[O:43])[C:44]2([C:47](=[O:48])[OH:49])[CH2:45][CH2:46]2)[cH:36][cH:37][cH:38][cH:39][cH:40]1.[n:64]1([O:65][P+:66]([N:67]([CH3:68])[CH3:69])([N:70]([CH3:71])[CH3:72])[N:73]([CH3:74])[CH3:75])[c:76]2[cH:77][cH:78][cH:79][cH:80][c:81]2[n:82][n:83]1>>[c:1]1([O:7][C:8]([N:9]([C:10](=[O:11])[O:12][c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[c:19]2[n:20][cH:21][cH:22][c:23]([O:25][c:26]3[cH:27][c:28]([F:33])[c:29]([NH:32][C:47]([C:44]4([C:42]([NH:41][c:35]5[cH:36][cH:37][cH:38][cH:39][cH:40]5)=[O:43])[CH2:45][CH2:46]4)=[O:48])[cH:30][cH:31]3)[cH:24]2)=[O:34])[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 124335Benzotriazol-1-yloxy-tris(dimethylamino)phosphoniumHCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acidHCID 67136032[4-(4-amino-3-fluorophenoxy)pyridin-2-yl]-N-(phenoxycarbonyl)carbamic acid phenyl ester

Product 1

HCID 59596979phenyl N-[4-(3-fluoro-4-{[1-(phenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyridin-2-yl]-N-phenoxycarbonylcarbamate

Sources & evidence

ORD record
ord-1f98457429fd4df19a8eee51d78bc9de
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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