Water → 1-(4-fluoro-2-nitrophenyl)piperidine

HRID 942636Notes

Reaction equation

HRID 942636 reaction equation
[CH2:1]1[CH2:2][CH2:3][NH:4][CH2:5][CH2:6]1.[CH3:7][N:8]([CH3:9])[CH:10]=[O:11].[F:12][c:13]1[c:14]([N+:20](=[O:21])[O-:22])[cH:15][c:16]([F:19])[cH:17][cH:18]1.[OH2:23]>>[CH2:1]1[CH2:2][CH2:3][N:4]([c:13]2[c:14]([N+:20](=[O:21])[O-:22])[cH:15][c:16]([F:19])[cH:17][cH:18]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 8082PiperidineHCID 677672,5-Difluoronitrobenzene

Product 1

HCID 27374341-(4-fluoro-2-nitrophenyl)piperidine

Sources & evidence

ORD record
ord-e12da2e5591b4e26abf0b888e5854e24
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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