Potassium Cation → 1-Tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

HRID 942818Notes

Reaction equation

HRID 942818 reaction equation
[C:17](=[O:18])([O-:19])[O-:20].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:14](=[O:15])[OH:16])[CH2:10][CH:11]([OH:13])[CH2:12]1.[CH3:23][I:24].[CH3:26][N:27]([CH3:28])[CH:29]=[O:30].[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[K+:21].[K+:22].[OH2:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:14](=[O:15])[O:16][CH3:17])[CH2:10][CH:11]([OH:13])[CH2:12]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 3352551-((Tert-butoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Product 1

HCID 51482991-Tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-f55cb85416f54dbca3c92af1dbedd275
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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