Methanol → N-[5-chloro-2-[2-[4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-2-oxoethoxy]phenyl]sulfonyl-2-hydroxy-2-methylpropanamide

HRID 942985Notes

Reaction equation

HRID 942985 reaction equation
[CH3:49][OH:50].[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:21][CH2:22][C:23](=[O:24])[N:25]2[CH:26]([CH3:40])[CH2:27][N:28]([CH2:32][c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[CH:29]([CH3:31])[CH2:30]2)[c:6]([S:8](=[O:9])(=[O:10])[NH:11][C:12]([C:13]([CH3:14])([CH3:15])[O:16][C:17](=[O:18])[CH3:19])=[O:20])[cH:7]1.[Li+:43].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[OH-:42].[OH2:41].[OH2:51]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:21][CH2:22][C:23](=[O:24])[N:25]2[CH:26]([CH3:40])[CH2:27][N:28]([CH2:32][c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[CH:29]([CH3:31])[CH2:30]2)[c:6]([S:8](=[O:9])(=[O:10])[NH:11][C:12]([C:13]([CH3:14])([CH3:15])[OH:16])=[O:20])[cH:7]1

Participants

7

Reactant 6

HCID 887MethanolHCID 961HydroxideHCID 962Water2×HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 178476293HCID 178476293, compound

Product 1

HCID 10144149N-[5-chloro-2-[2-[4-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazin-1-yl]-2-oxoethoxy]phenyl]sulfonyl-2-hydroxy-2-methylpropanamide

Sources & evidence

ORD record
ord-d7295d342bba41b79b5ac3c3c2ad96a6
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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