Ammonium → 4-[[2-[5-[[Boc(2-methoxyethyl)amino]methyl]-2-pyridyl]-7-thieno[3,2-b]pyridyl]oxy]-3-fluoroaniline

HRID 943192Notes

Reaction equation

HRID 943192 reaction equation
[CH3:43][CH2:44][OH:45].[Cl-:40].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([CH2:20][N:21]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:29][CH2:30][O:31][CH3:32])[cH:18][n:19]2)[s:13]3)[cH:33][cH:34][c:35]([N+:37]([O-:38])=[O:39])[cH:36]1.[Fe:42].[NH4+:41].[OH2:46]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12](-[c:14]2[cH:15][cH:16][c:17]([CH2:20][N:21]([C:22]([O:23][C:24]([CH3:25])([CH3:26])[CH3:27])=[O:28])[CH2:29][CH2:30][O:31][CH3:32])[cH:18][n:19]2)[s:13]3)[cH:33][cH:34][c:35]([NH2:37])[cH:36]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 312ChlorideHCID 702EthanolHCID 962WaterHCID 23925IronHCID 57919594tert-Butyl (6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

Product 1

HCID 579194724-[[2-[5-[[Boc(2-methoxyethyl)amino]methyl]-2-pyridyl]-7-thieno[3,2-b]pyridyl]oxy]-3-fluoroaniline

Sources & evidence

ORD record
ord-2d33bbd0fe434d1d8b51ca5ba1cec50f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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