Tetrahydrofuran → 2-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate

HRID 943425Notes

Reaction equation

HRID 943425 reaction equation
[CH2:1]([CH:2]=[CH2:3])[O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][c:10]([C:11]([O:13][CH2:12][CH3:14])=[O:15])[cH:16][cH:17][cH:18]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:28][Si:29]([N-:30][Si:31]([CH3:32])([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Cl:19][c:20]1[n:21][cH:22][cH:23][c:24]([CH3:26])[n:25]1.[Li+:27]>>[CH2:1]([CH:2]=[CH2:3])[O:4][C:5](=[O:6])[NH:7][c:8]1[cH:9][c:10]([C:11](=[O:13])[CH2:26][c:24]2[cH:23][cH:22][n:21][c:20]([Cl:19])[n:25]2)[cH:16][cH:17][cH:18]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 116296072-Chloro-4-methylpyrimidineHCID 57989833Ethyl 3-{[(2-propen-1-yloxy)carbonyl]amino}benzoate

Product 1

HCID 579899812-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate

Sources & evidence

ORD record
ord-faca36954f44424885301389e96ff4ed
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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