1,2-Dichloroethane → Tert-butyl 4-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

HRID 943685Notes

Reaction equation

HRID 943685 reaction equation
[C:19](=[O:20])([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[N:26]1[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]1.[C:39]([O:40][BH-:41]([O:42][C:43](=[O:44])[CH3:45])[O:46][C:47](=[O:48])[CH3:49])(=[O:50])[CH3:51].[CH3:32][O:33][CH:34]([O:35][CH3:36])[O:37][CH3:38].[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[O:12])[s:10]2.[Cl:53][CH2:54][CH2:55][Cl:56].[Na+:52]>>[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:29]1[CH2:28][CH2:27][N:26]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:31][CH2:30]1)[s:10]2

Participants

7

Reactant 6

HCID 111,2-DichloroethaneHCID 923Sodium ionHCID 9005Trimethyl orthoformateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2724942TriacetoxyborohydrideHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 57494058Tert-butyl 4-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-630f2de9fb9042b9a5f4264f71445777
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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