Toluene → 4-(Hydroxymethyl)-2-Isopropylthiazole

HRID 943743Notes

Reaction equation

HRID 943743 reaction equation
[Al+3:2].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1.[CH:7]([CH3:8])([CH3:9])[c:10]1[s:11][cH:12][c:13]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[n:14]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[CH:7]([CH3:8])([CH3:9])[c:10]1[s:11][cH:12][c:13]([CH2:15][OH:16])[n:14]1

Participants

7

Reactant 6

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 10535999Ethyl 2-isopropylthiazole-4-carboxylate

Product 1

HCID 105349374-(Hydroxymethyl)-2-Isopropylthiazole

Sources & evidence

ORD record
ord-4ba40a71165f447ba97c1e11c892a91b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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