Methanol → Tert-butyl 4-(4-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylate

HRID 944183Notes

Reaction equation

HRID 944183 reaction equation
[BH3:29].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([C:14](=[O:15])[OH:16])([c:17]2[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]2)[CH2:12][CH2:13]1.[CH3:30][OH:31].[CH3:37][CH2:38][O:39][C:40](=[O:41])[CH3:42].[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][OH:15])([c:17]2[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 8857Ethyl AcetateHCID 450740231-(tert-Butoxycarbonyl)-4-(4-fluorophenyl)piperidine-4-carboxylic acid

Product 1

HCID 19084679Tert-butyl 4-(4-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8116214638d748f3bafdb302b0f93228
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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