Ethyl Acetate → 1-Boc-4-(4-Nitrophenyl)piperazine

HRID 944193Notes

Reaction equation

HRID 944193 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]1.[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[CH:24]([N:25]([CH2:26][CH3:27])[CH:28]([CH3:29])[CH3:30])([CH3:31])[CH3:32].[F:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[cH:6][cH:7]1>>[c:2]1([N:21]2[CH2:20][CH2:19][N:18]([C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:17])[CH2:23][CH2:22]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8857Ethyl AcetateHCID 9590p-FluoronitrobenzeneHCID 81531DiisopropylethylamineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 33806961-Boc-4-(4-Nitrophenyl)piperazine

Sources & evidence

ORD record
ord-a949405f2a7c4994afa3073c95dbf91e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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