Tetrahydrofuran → HCID 57751898, compound

HRID 94433Notes

Reaction equation

[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:48][CH2:49][O:50][C:51](=[O:52])[CH3:53].[F:1][c:2]1[c:3]([C:39]([F:40])([F:41])[F:42])[cH:4][c:5](-[c:8]2[n:9][c:10]([CH:14]3[CH2:15][CH2:16][N:17]([c:20]4[c:21]5[c:22]([n:23][cH:24][n:25]4)[nH:26][cH:27][c:28]5[C:29]#[C:30][C:31]([CH3:32])([O:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[CH3:38])[CH2:18][CH2:19]3)[n:11]([CH3:13])[cH:12]2)[cH:6][cH:7]1>>[F:1][c:2]1[c:3]([C:39]([F:40])([F:41])[F:42])[cH:4][c:5](-[c:8]2[n:9][c:10]([CH:14]3[CH2:15][CH2:16][N:17]([c:20]4[c:21]5[c:22]([n:23][cH:24][n:25]4)[nH:26][cH:27][c:28]5[C:29]#[C:30][C:31]([CH3:32])([OH:33])[CH3:38])[CH2:18][CH2:19]3)[n:11]([CH3:13])[cH:12]2)[cH:6][cH:7]1

Participants

Reactant 3

HCID 8028Tetrahydrofuran

HCID 8857Ethyl Acetate

HCID 666500304-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-5-(3-methyl-3-(trimethylsilyloxy)but-1-ynyl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 57751898HCID 57751898, compound

Sources & evidence

ORD record: ord-f8ac3abe4829484db32b992e433984ac
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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