1,2-Dichloroethane → N-t-Butoxycarbonyl-5-[(morpholin-4-yl)carbonyl]isoindoline

HRID 944620Notes

Reaction equation

HRID 944620 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17](=[O:18])[OH:19])[cH:14][c:15]2[CH2:16]1.[CH2:20]([Cl:21])[CH2:22][Cl:23].[CH2:31]1[CH2:32][O:33][CH2:34][CH2:35][NH:36]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:37][CH2:38][Cl:39]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([C:17](=[O:19])[N:36]3[CH2:31][CH2:32][O:33][CH2:34][CH2:35]3)[cH:14][c:15]2[CH2:16]1

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 6344DichloromethaneHCID 8083MorpholineHCID 8471TriethylamineHCID 164501432-(tert-Butoxycarbonyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid

Product 1

HCID 17986287N-t-Butoxycarbonyl-5-[(morpholin-4-yl)carbonyl]isoindoline

Sources & evidence

ORD record
ord-1e1238c97e97431db635ef0d3ad8f643
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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