Dimethylformamide → 4-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-1-(oxan-2-yl)-3-(3-pyrrolidin-1-ylprop-1-ynyl)pyrazolo[5,4-d]pyrimidine

HRID 944749Notes

Reaction equation

HRID 944749 reaction equation
[CH2:38]1[CH2:39][CH2:40][NH:41][CH2:42]1.[CH3:1][S:2]([O:3][CH2:6][C:7]#[C:8][c:9]1[n:10][n:11]([CH:32]2[O:33][CH2:34][CH2:35][CH2:36][CH2:37]2)[c:12]2[n:13][cH:14][n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([c:24]4[c:25]([CH3:31])[cH:26][cH:27][c:28]([Cl:30])[cH:29]4)[CH2:22][CH2:23]3)[c:17]12)(=[O:4])=[O:5].[O:43]=[CH:44][N:45]([CH3:46])[CH3:47]>>[CH2:6]([C:7]#[C:8][c:9]1[n:10][n:11]([CH:32]2[O:33][CH2:34][CH2:35][CH2:36][CH2:37]2)[c:12]2[n:13][cH:14][n:15][c:16]([N:18]3[CH2:19][CH2:20][N:21]([c:24]4[c:25]([CH3:31])[cH:26][cH:27][c:28]([Cl:30])[cH:29]4)[CH2:22][CH2:23]3)[c:17]12)[N:41]1[CH2:40][CH2:39][CH2:38][CH2:42]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 31268PyrrolidineHCID 866193953-[4-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-1-(oxan-2-yl)pyrazolo[5,4-d]pyrimidin-3-yl]prop-2-ynyl methanesulfonate

Product 1

HCID 692454444-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]-1-(oxan-2-yl)-3-(3-pyrrolidin-1-ylprop-1-ynyl)pyrazolo[5,4-d]pyrimidine

Sources & evidence

ORD record
ord-08899ff6eeef43dd862cc3c035b4c7b9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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