Toluene → Ethyl 2-[3-[[4-(cyclopropylmethoxy)oxolan-3-yl]amino]-2-oxopyrazin-1-yl]acetate

HRID 945102Notes

Reaction equation

HRID 945102 reaction equation
[Br:12][c:13]1[c:14](=[O:25])[n:15]([CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:16][cH:17][n:18]1.[CH3:35][c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1.[CH3:42][CH2:43][O:44][C:45]([CH3:46])=[O:47].[CH:1]1([CH2:4][O:5][CH:6]2[CH2:7][O:8][CH2:9][CH:10]2[NH2:11])[CH2:2][CH2:3]1.[CH:26]([N:27]([CH2:28][CH3:29])[CH:30]([CH3:31])[CH3:32])([CH3:33])[CH3:34]>>[CH:1]1([CH2:4][O:5][CH:6]2[CH2:7][O:8][CH2:9][CH:10]2[NH:11][c:13]2[c:14](=[O:25])[n:15]([CH2:19][C:20](=[O:21])[O:22][CH2:23][CH3:24])[cH:16][cH:17][n:18]2)[CH2:2][CH2:3]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 11807445(3-Bromo-2-oxo-2H-pyrazin-1-yl)-acetic Acid Ethyl EsterHCID 230002244-(Cyclopropylmethoxy)oxolan-3-amine

Product 1

HCID 70024747Ethyl 2-[3-[[4-(cyclopropylmethoxy)oxolan-3-yl]amino]-2-oxopyrazin-1-yl]acetate

Sources & evidence

ORD record
ord-b54baa4764a74ca0b92795fc668f706b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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