Bicarbonate Ion → Tert-butyl 1-[2-(7-nitro-2,3-dihydro-1,4-benzothiazin-4-yl)-2-oxoethyl]pyrrolidine-2-carboxylate

HRID 945128Notes

Reaction equation

HRID 945128 reaction equation
[C:41](=[O:42])([OH:43])[O-:44].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40].[Cl:1][CH2:2][C:3](=[O:4])[N:5]1[c:6]2[c:7]([cH:11][c:12]([N+:15](=[O:16])[O-:17])[cH:13][cH:14]2)[S:8][CH2:9][CH2:10]1.[NH:18]1[CH:19]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:20][CH2:21][CH2:22]1.[Na+:45]>>[CH2:2]([C:3](=[O:4])[N:5]1[c:6]2[c:7]([cH:11][c:12]([N+:15](=[O:16])[O-:17])[cH:13][cH:14]2)[S:8][CH2:9][CH2:10]1)[N:18]1[CH:19]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:20][CH2:21][CH2:22]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 102884tert-butyl L-prolinateHCID 591440782-Chloro-1-(7-nitro-2H-benzo[b][1,4]thiazin-4(3H)-yl)ethanone

Product 1

HCID 66704655Tert-butyl 1-[2-(7-nitro-2,3-dihydro-1,4-benzothiazin-4-yl)-2-oxoethyl]pyrrolidine-2-carboxylate

Sources & evidence

ORD record
ord-453156054436402c947c4e563a692e73
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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