Ethylene Glycol → Tert-butyl 3-(3-chloro-4-fluoroanilino)pyrrolidine-1-carboxylate

HRID 945245Notes

Reaction equation

HRID 945245 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([NH2:13])[CH2:11][CH2:12]1.[CH:37]([OH:38])([CH3:39])[CH3:40].[Cl:14][c:15]1[c:16]([F:22])[cH:17][cH:18][c:19]([I:21])[cH:20]1.[Cu:35][I:36].[K+:32].[K+:33].[K+:34].[OH:23][CH2:24][CH2:25][OH:26].[P:27]([O-:28])([O-:29])([O-:30])=[O:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([NH:13][c:19]2[cH:18][cH:17][c:16]([F:22])[c:15]([Cl:14])[cH:20]2)[CH2:11][CH2:12]1

Participants

8

Reactant 7

HCID 174Ethylene GlycolHCID 813Potassium Cation3×HCID 1061PhosphateHCID 3776IsopropanolHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27246052-Chloro-1-fluoro-4-iodobenzeneHCID 27563701-Boc-3-aminopyrrolidine

Product 1

HCID 66657070Tert-butyl 3-(3-chloro-4-fluoroanilino)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-0f9534dfd81a466da77de1d66b58d086
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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