Hydrochloric Acid → 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-cyano-1,5-naphthyridin-2(1H)-one

HRID 945480Notes

Reaction equation

HRID 945480 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9](=[O:29])[n:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:11]2[cH:12]1.[C:30]([O:31][CH2:32][CH3:33])(=[O:34])[CH3:35].[C:37](=[O:38])([O-:39])[OH:40].[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[ClH:36].[Na+:41]>>[C:1](#[N:2])[c:3]1[cH:4][n:5][c:6]2[cH:7][cH:8][c:9](=[O:29])[n:10]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:11]2[cH:12]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ionHCID 8857Ethyl Acetate2×HCID 71248370tert-butyl (1-(2-(7-cyano-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate

Product 1

HCID 688165971-(2-(4-aminopiperidin-1-yl)ethyl)-7-cyano-1,5-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-43b67c6f5b1547ee95fbc935c14b7ec4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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