Tetrahydrofuran → 4-[8-(t-Butyldimethylsilyloxy)-1-octynyl]-4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-3-methylthiochroman

HRID 945514Notes

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[CH:14])([CH3:15])[CH3:16].[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[CH3:22][O:23][c:24]1[cH:25][cH:26][c:27]2[c:32]([cH:33]1)[S:31][CH2:30][C:29]([CH3:34])([c:35]1[cH:36][cH:37][c:38]([O:41][CH3:42])[cH:39][cH:40]1)[C:28]2=[O:43].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:28]1([OH:43])[c:27]2[cH:26][cH:25][c:24]([O:23][CH3:22])[cH:33][c:32]2[S:31][CH2:30][C:29]1([CH3:34])[c:35]1[cH:36][cH:37][c:38]([O:41][CH3:42])[cH:39][cH:40]1)([CH3:15])[CH3:16]