Dimethylformamide → 4-(2-Cyclohex-1-enyl-6-pyrrolidine-1-yl-pyridine-4-sulfonyl)-phenylamine

HRID 945551Notes

Reaction equation

HRID 945551 reaction equation
[Br:1][c:2]1[n:3][c:4]([N:18]2[CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:5][c:6]([S:8](=[O:9])(=[O:10])[c:11]2[cH:12][cH:13][c:14]([NH2:17])[cH:15][cH:16]2)[cH:7]1.[CH2:23]([Sn:24]([CH2:25][CH2:26][CH2:27][CH3:34])([C:28]1=[CH:29][CH2:30][CH2:31][CH2:32][CH2:33]1)[CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41].[CH3:42][N:43]([CH3:44])[CH:45]=[O:46].[Pd:47]([Cl:48])[Cl:49].[c:50]1([P:51]([c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)[cH:64][cH:65][cH:66][cH:67][cH:68]1.[c:69]1([P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[cH:83][cH:84][cH:85][cH:86][cH:87]1>>[c:2]1([C:28]2=[CH:29][CH2:30][CH2:31][CH2:32][CH2:33]2)[n:3][c:4]([N:18]2[CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:5][c:6]([S:8](=[O:9])(=[O:10])[c:11]2[cH:12][cH:13][c:14]([NH2:17])[cH:15][cH:16]2)[cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 69186894-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamineHCID 11783615Stannane, tributyl-1-cyclohexen-1-yl-

Product 1

HCID 196054654-(2-Cyclohex-1-enyl-6-pyrrolidine-1-yl-pyridine-4-sulfonyl)-phenylamine

Sources & evidence

ORD record
ord-e7a49373d02b4147af5fca4c0bdb0aaa
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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