Dichloromethane → 4-({Ethyl-[7-(4-methanesulfonyl-benzoylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amino}-methyl)-piperidine-1-carboxylic acid isopropylamide

HRID 945847Notes

Reaction equation

HRID 945847 reaction equation
[CH2:1]([CH3:2])[N:3]([CH:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][c:10]([NH:14][C:15]([c:16]3[cH:17][cH:18][c:19]([S:22](=[O:23])(=[O:24])[CH3:25])[cH:20][cH:21]3)=[O:26])[cH:11][c:12]2[CH2:13]1)[CH2:27][CH:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1.[CH2:47]([Cl:48])[Cl:49].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[CH:41]([CH3:42])([CH3:43])[N:44]=[C:45]=[O:46]>>[CH2:1]([CH3:2])[N:3]([CH:4]1[CH2:5][CH2:6][c:7]2[cH:8][cH:9][c:10]([NH:14][C:15]([c:16]3[cH:17][cH:18][c:19]([S:22](=[O:23])(=[O:24])[CH3:25])[cH:20][cH:21]3)=[O:26])[cH:11][c:12]2[CH2:13]1)[CH2:27][CH:28]1[CH2:29][CH2:30][N:31]([C:45]([NH:44][CH:41]([CH3:42])[CH3:43])=[O:46])[CH2:32][CH2:33]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 61277Isopropyl isocyanateHCID 11248400N-[7-(ethyl-piperidin-4-ylmethyl-amino)-5,6,7,8-tetrahydro-naphthalen-2-yl]-4-methanesulfonyl-benzamide

Product 1

HCID 113074364-({Ethyl-[7-(4-methanesulfonyl-benzoylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amino}-methyl)-piperidine-1-carboxylic acid isopropylamide

Sources & evidence

ORD record
ord-bdd991ee916947bd96e4649d02e41db9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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