Potassium Cation → tert-butyl 2-[[5-(6-hydroxyhex-1-ynyl)-3-pyridinyl]oxymethyl]azetidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([O:8][CH2:9][CH:10]2[N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:5][n:6][cH:7]1.[CH2:46]([CH2:47][CH2:48][CH2:49][C:50]#[CH:51])[OH:52].[CH3:53][O:54][CH2:55][CH2:56][O:57][CH3:58].[Cu:60][I:61].[K+:21].[K+:22].[O-:23][C:24]([O-:25])=[O:26].[OH2:59].[c:27]1([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[cH:41][cH:42][cH:43][cH:44][cH:45]1>>[c:2]1([C:51]#[C:50][CH2:49][CH2:48][CH2:47][CH2:46][OH:52])[cH:3][c:4]([O:8][CH2:9][CH:10]2[N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]2)[cH:5][n:6][cH:7]1Participants
9
Reactant 8
HCID 813Potassium Cation2×
HCID 962Water
HCID 80711,2-Dimethoxyethane
HCID 11776Triphenylphosphine
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 702345-Hexyn-1-ol
HCID 18459001Tert-butyl 2-(((5-bromopyridin-3-YL)oxy)methyl)azetidine-1-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-39d06d3f116247bd946a3b5893601ea1
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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