Tetrahydrofuran → 1-Benzyl-4-(N-methyl-N-(3-hydroxymethyl-2-pyridyl)amino)piperidine

HRID 946433Notes

Reaction equation

HRID 946433 reaction equation
[Al+3:27].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([c:15]2[n:16][cH:17][cH:18][cH:19][c:20]2[C:21](=[O:22])[O:23][CH3:24])[CH3:25])[CH2:12][CH2:13]1.[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([c:15]2[n:16][cH:17][cH:18][cH:19][c:20]2[CH2:21][OH:22])[CH3:25])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 10759534HCID 10759534, compound

Product 1

HCID 106387941-Benzyl-4-(N-methyl-N-(3-hydroxymethyl-2-pyridyl)amino)piperidine

Sources & evidence

ORD record
ord-f82b697d0dfd4b85b241edb09e7d9faf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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