Sulfuric Acid → 1,3-Diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol

HRID 946450Notes

Reaction equation

HRID 946450 reaction equation
[C:11]([CH:12]([CH3:13])[CH3:14])(=[O:15])[O:16][CH2:17][C:18](=[O:19])[CH2:20][O:21][C:22]([CH:23]([CH3:24])[CH3:25])=[O:26].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[F:2][c:3]1[c:4]([Br:10])[cH:5][cH:6][c:7]([F:9])[cH:8]1.[Mg:1].[S:27](=[O:28])(=[O:29])([OH:30])[OH:31]>>[F:2][c:3]1[c:4]([C:18]([CH2:17][O:16][C:11]([CH:12]([CH3:13])[CH3:14])=[O:15])([OH:19])[CH2:20][O:21][C:22]([CH:23]([CH3:24])[CH3:25])=[O:26])[cH:5][cH:6][c:7]([F:9])[cH:8]1

Participants

6

Reactant 5

HCID 1118Sulfuric AcidHCID 8028TetrahydrofuranHCID 676741-Bromo-2,4-difluorobenzeneHCID 5462224MagnesiumHCID 155218061,3-Diisobutyryloxyacetone

Product 1

HCID 112908691,3-Diisobutyryloxy-2-(2,4-difluorophenyl)-2-propanol

Sources & evidence

ORD record
ord-78b828317d2643779e778bb88798f25b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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