Trifluoroacetic acid → 2-(3-Bromo-phenyl)-8-chloro-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid methyl ester
Reaction equation
[CH2:26]([SiH:27]([CH2:28][CH3:29])[CH2:30][CH3:31])[CH3:32].[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]2[c:11]([c:12]([Cl:15])[cH:13][cH:14]1)[NH:10][CH:9]([c:16]1[cH:17][c:18]([Br:22])[cH:19][cH:20][cH:21]1)[C:8]([CH3:23])([CH3:24])[CH:7]2[OH:25].[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[c:6]2[c:11]([c:12]([Cl:15])[cH:13][cH:14]1)[NH:10][CH:9]([c:16]1[cH:17][c:18]([Br:22])[cH:19][cH:20][cH:21]1)[C:8]([CH3:23])([CH3:24])[CH2:7]2Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-46916d442138423daa32708074c6a99a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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