Tetrahydrofuran → 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-(pyrrolidin-1-yl)-5-(trifluoromethyl)picolinic acid
Reaction equation
[Br:1][c:2]1[c:3]([C:18]([F:19])([F:20])[F:21])[cH:4][c:5](-[n:11]2[c:12]([CH3:17])[cH:13][cH:14][c:15]2[CH3:16])[c:6]([C:8](=[O:9])[OH:10])[n:7]1.[CH2:22]1[CH2:23][CH2:24][NH:25][CH2:26]1.[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1>>[c:2]1([N:25]2[CH2:24][CH2:23][CH2:22][CH2:26]2)[c:3]([C:18]([F:19])([F:20])[F:21])[cH:4][c:5](-[n:11]2[c:12]([CH3:17])[cH:13][cH:14][c:15]2[CH3:16])[c:6]([C:8](=[O:9])[OH:10])[n:7]1Participants
4
Sources & evidence
- ORD record
- ord-68e785d066a545f1a69669378797fe97
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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