Chloride → Benzyl 4-formylpiperidine-1-carboxylate

HRID 946945Notes

Reaction equation

HRID 946945 reaction equation
[CH3:21][CH:22]([CH2:23][AlH:24][CH2:25][CH:26]([CH3:27])[CH3:28])[CH3:29].[CH3:30][OH:31].[CH3:34][c:35]1[cH:36][cH:37][cH:38][cH:39][cH:40]1.[Cl-:33].[N:1]1([C:11](=[O:12])[O:13][CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[O:9][CH3:10])[CH2:5][CH2:6]1.[Na+:32]>>[N:1]1([C:11](=[O:12])[O:13][CH2:14][c:15]2[cH:16][cH:17][cH:18][cH:19][cH:20]2)[CH2:2][CH2:3][CH:4]([CH:7]=[O:8])[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 887MethanolHCID 923Sodium ionHCID 1140TolueneHCID 14487Diisobutylaluminum hydrideHCID 15125441-Benzyl 4-methyl piperidine-1,4-dicarboxylate

Product 1

HCID 2776272Benzyl 4-formylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-aaaa9e6adee64a46ac7ea4fa357824c2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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