4-Aminophenol → 4-(4-Aminophenoxy)-N-methylpicolinamide

HRID 946949Notes

Reaction equation

HRID 946949 reaction equation
[Cl:11][c:12]1[cH:13][c:14]([C:18](=[O:19])[NH:20][CH3:21])[n:15][cH:16][cH:17]1.[H-:10].[K+:22].[K+:23].[NH2:1][c:2]1[cH:3][cH:4][c:5]([OH:6])[cH:7][cH:8]1.[Na+:9].[O-:24][C:25]([O-:26])=[O:27].[O:28]=[CH:29][N:30]([CH3:31])[CH3:32]>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:12]2[cH:13][c:14]([C:18](=[O:19])[NH:20][CH3:21])[n:15][cH:16][cH:17]2)[cH:7][cH:8]1

Participants

8

Reactant 7

HCID 4034-AminophenolHCID 813Potassium Cation2×HCID 923Sodium ionHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 166653HydrideHCID 14768144-Chloro-N-methylpicolinamide

Product 1

HCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

Sources & evidence

ORD record
ord-dafb947fdfd849ec999fb9ac464d3143
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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