Water → tert-butyl N-[4-[3-(3-methyl-5-nitro-2-pyridinyl)phenyl]sulfonyl-5-methylsulfanylthiophene-2-carboximidoyl]carbamate

HRID 947506Notes

Reaction equation

HRID 947506 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8](=[NH:9])[c:10]1[s:11][c:12]([S:27][CH3:28])[c:13]([S:15](=[O:16])(=[O:17])[c:18]2[cH:19][c:20]([B:24]([OH:25])[OH:26])[cH:21][cH:22][cH:23]2)[cH:14]1)=[O:29].[Cu:47][I:48].[I:30][c:31]1[n:32][cH:33][c:34]([N+:38](=[O:39])[O-:40])[cH:35][c:36]1[CH3:37].[O:42]=[CH:43][N:44]([CH3:45])[CH3:46].[OH2:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8](=[NH:9])[c:10]1[s:11][c:12]([S:27][CH3:28])[c:13]([S:15](=[O:16])(=[O:17])[c:18]2[cH:19][c:20](-[c:31]3[n:32][cH:33][c:34]([N+:38](=[O:39])[O-:40])[cH:35][c:36]3[CH3:37])[cH:21][cH:22][cH:23]2)[cH:14]1)=[O:29]

Participants

6

Reactant 5

HCID 962WaterHCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 218867642-Iodo-3-methyl-5-nitropyridineHCID 140043492[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]boronic acid

Product 1

HCID 145857668tert-butyl N-[4-[3-(3-methyl-5-nitro-2-pyridinyl)phenyl]sulfonyl-5-methylsulfanylthiophene-2-carboximidoyl]carbamate

Sources & evidence

ORD record
ord-7dbcf5a051c8448a8e0aba39b049b9ab
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…