Tetrahydrofuran → Methyl 3-cyclopentyl-2-(3-methylsulfonyl-1,2,4-triazol-1-yl)propanoate

HRID 947547Notes

Reaction equation

HRID 947547 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:10][Si:11]([N-:12][Si:13]([CH3:14])([CH3:15])[CH3:16])([CH3:17])[CH3:18].[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[n:6][nH:7][cH:8][n:9]1.[CH:20]1([CH2:25][CH:26]([C:27](=[O:28])[O:29][CH3:30])[O:31][S:32]([C:33]([F:34])([F:35])[F:36])(=[O:37])=[O:38])[CH2:21][CH2:22][CH2:23][CH2:24]1.[Li+:19]>>[CH3:1][S:2](=[O:3])(=[O:4])[c:5]1[n:6][n:7]([CH:26]([CH2:25][CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24]2)[C:27](=[O:28])[O:29][CH3:30])[cH:8][n:9]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 76447312(R)-Methyl 3-cyclopentyl-2-(((trifluoromethyl)sulfonyl)oxy)propanoateHCID 178504852HCID 178504852, compound

Product 1

HCID 67313984Methyl 3-cyclopentyl-2-(3-methylsulfonyl-1,2,4-triazol-1-yl)propanoate

Sources & evidence

ORD record
ord-1fd51a872a2a457782621a18b1f43cc6
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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