1,4-Dibromobenzene → (4-Bromophenyl)(4-fluorophenyl)methanol

HRID 947769Notes

Reaction equation

HRID 947769 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([Br:6])[cH:7][cH:8]1.[CH2:23]1[O:24][CH2:25][CH2:26][CH2:27]1.[CH3:28][CH2:29][O:30][C:31]([CH3:32])=[O:33].[CH3:9][CH2:10][CH2:11][CH2:12][Li:13].[F:14][c:15]1[cH:16][cH:17][c:18]([CH:19]=[O:20])[cH:21][cH:22]1>>[c:2]1([CH:19]([c:18]2[cH:17][cH:16][c:15]([F:14])[cH:22][cH:21]2)[OH:20])[cH:3][cH:4][c:5]([Br:6])[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 78041,4-DibromobenzeneHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 680234-FluorobenzaldehydeHCID 178418339Butyllithium

Product 1

HCID 13354004(4-Bromophenyl)(4-fluorophenyl)methanol

Sources & evidence

ORD record
ord-434cdb04eb48477db261a5b5384ba603
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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