Hydrochloric Acid → 1-(3-(2-(1-Benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol

HRID 947980Notes

Reaction equation

HRID 947980 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[CH3:30][S:31](=[O:32])[CH3:33].[CH3:34][CH2:35][O:36][C:37](=[O:38])[CH3:39].[Cl:1][CH2:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][c:8]1[cH:9][c:10]2[c:11]([cH:12][cH:13][s:14]2)[cH:15][cH:16]1.[ClH:17].[ClH:29].[K+:27].[K+:28].[NH:18]1[CH2:19][CH:20]([OH:22])[CH2:21]1.[OH2:40]>>[CH2:2]([CH2:3][CH2:4][O:5][CH2:6][CH2:7][c:8]1[cH:9][c:10]2[c:11]([cH:12][cH:13][s:14]2)[cH:15][cH:16]1)[N:18]1[CH2:19][CH:20]([OH:22])[CH2:21]1

Participants

9

Reactant 8

HCID 313Hydrochloric Acid2×HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 15142903-HydroxyazetidineHCID 219900846-(2-(3-Chloropropoxy)ethyl)-1-benzothiophene

Product 1

HCID 235455641-(3-(2-(1-Benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol

Sources & evidence

ORD record
ord-1fa710a5550b490e93a9133bdb2d432a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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