Toluene → 2-Methyl-5-nitropyridine

HRID 948252Notes

Reaction equation

HRID 948252 reaction equation
[C:1]([O:2][CH2:3][CH3:4])(=[O:5])[CH2:6][C:7]([O:8][CH2:9][CH3:10])=[O:11].[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[Cl:13][c:14]1[n:15][cH:16][c:17]([N+:20](=[O:21])[O-:22])[cH:18][cH:19]1.[Na:12]>>[CH3:1][c:14]1[n:15][cH:16][c:17]([N+:20](=[O:21])[O-:22])[cH:18][cH:19]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 7761Diethyl MalonateHCID 783082-Chloro-5-nitropyridineHCID 5360545Sodium

Product 1

HCID 27945522-Methyl-5-nitropyridine

Sources & evidence

ORD record
ord-c314bad1be8a4d8eace7bcd968382e34
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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