N-methyl-2-pyrrolidone → Grepafloxacin

HRID 948532Notes

Reaction equation

HRID 948532 reaction equation
[CH3:21][CH:22]1[CH2:23][NH:24][CH2:25][CH2:26][NH:27]1.[CH3:28][N:29]1[CH2:30][CH2:31][CH2:32][C:33]1=[O:34].[CH:1]1([n:4]2[cH:5][c:6]([C:18](=[O:19])[OH:20])[c:7](=[O:17])[c:8]3[c:9]([CH3:16])[c:10]([F:15])[c:11]([Br:14])[cH:12][c:13]23)[CH2:2][CH2:3]1>>[CH:1]1([n:4]2[cH:5][c:6]([C:18](=[O:19])[OH:20])[c:7](=[O:17])[c:8]3[c:9]([CH3:16])[c:10]([F:15])[c:11]([N:24]4[CH2:23][CH:22]([CH3:21])[NH:27][CH2:26][CH2:25]4)[cH:12][c:13]23)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 660572-MethylpiperazineHCID 101320157-Bromo-1-cyclopropyl-6-fluoro-5-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 72474Grepafloxacin

Sources & evidence

ORD record
ord-c5a573613ae3411c9f9d6bc2412592a2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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