Hydrochloric Acid → Hydrochloric Acid

HRID 948751Notes

Reaction equation

HRID 948751 reaction equation
[C:31](=[O:32])([O-:33])[O-:34].[CH3:37][I:38].[CH3:40][N:41]([CH3:42])[CH:43]=[O:44].[CH3:45][CH2:46][O:47][CH2:48][CH3:49].[ClH:39].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][O:14][CH:15]2[C:16]3([c:23]4[cH:24][cH:25][cH:26][cH:27][cH:28]4)[CH2:17][CH2:18][CH:19]([CH2:20][CH2:21]2)[NH:22]3)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:29])[F:30].[K+:35].[K+:36].[OH2:50]>>[ClH:39].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:13][O:14][CH:15]2[C:16]3([c:23]4[cH:24][cH:25][cH:26][cH:27][cH:28]4)[CH2:17][CH2:18][CH:19]([CH2:20][CH2:21]2)[N:22]3[CH3:31])[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:29])[F:30]

Participants

10

Reactant 8

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 962WaterHCID 3283Diethyl EtherHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 19660Carbonate IonHCID 227245802-(3,5-Bis(trifluoromethyl)benzyloxy)-1-phenyl-8-aza-bicyclo[3.2.1]octane

Product 2

HCID 313Hydrochloric AcidHCID 880392572-[[3,5-Bis(trifluoromethyl)phenyl]methoxy]-8-methyl-1-phenyl-8-azabicyclo[3.2.1]octane

Sources & evidence

ORD record
ord-057cb61392bc4d3d8177c6db402e39f3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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