Tetrahydrofuran → 4-(1,4-Dimethylpiperidin-4-yl)aniline

HRID 948828Notes

Reaction equation

HRID 948828 reaction equation
[Al+3:21].[CH2:26]1[O:27][CH2:28][CH2:29][CH2:30]1.[H-:20].[H-:23].[H-:24].[H-:25].[Li+:22].[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH3:19])[CH2:9][CH2:10][N:11]([C:14]([O:15][CH2:16][CH3:17])=[O:18])[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([CH3:19])[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 57489652Ethyl 4-(4-aminophenyl)-4-methylpiperidine-1-carboxylate

Product 1

HCID 574896554-(1,4-Dimethylpiperidin-4-yl)aniline

Sources & evidence

ORD record
ord-f789bea51ad24722987c0b01bcb91103
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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