Tetrahydrofuran → 1-Acridinol, 1,2,3,4-tetrahydro-6-fluoro-9-(((2-(trifluoromethyl)phenyl)methyl)amino)-

HRID 949051Notes

Reaction equation

HRID 949051 reaction equation
[Al+3:30].[F:1][c:2]1[cH:3][c:4]2[n:5][c:6]3[c:11]([c:12]([NH:16][CH2:17][c:18]4[c:19]([C:24]([F:25])([F:26])[F:27])[cH:20][cH:21][cH:22][cH:23]4)[c:13]2[cH:14][cH:15]1)[C:10](=[O:28])[CH2:9][CH2:8][CH2:7]3.[H-:29].[H-:32].[H-:33].[H-:34].[Li+:31].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[F:1][c:2]1[cH:3][c:4]2[n:5][c:6]3[c:11]([c:12]([NH:16][CH2:17][c:18]4[c:19]([C:24]([F:25])([F:26])[F:27])[cH:20][cH:21][cH:22][cH:23]4)[c:13]2[cH:14][cH:15]1)[CH:10]([OH:28])[CH2:9][CH2:8][CH2:7]3

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 139351393,4-dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)acridin-1(2H)-one

Product 1

HCID 30256251-Acridinol, 1,2,3,4-tetrahydro-6-fluoro-9-(((2-(trifluoromethyl)phenyl)methyl)amino)-

Sources & evidence

ORD record
ord-2415a79b82b64b2db767fb9b927364f2
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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