Dimethylformamide → 4-((S)-4-((R)-1-Phenylethyl)morpholin-2-yl)benzaldehyde

HRID 949239Notes

Reaction equation

HRID 949239 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[O:9][CH2:10][CH2:11][N:12]([CH:14]([CH3:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[CH2:13]2)[cH:6][cH:7]1.[CH2:22]([Li:23])[CH2:24][CH2:25][CH3:26].[CH3:27][N:28]([CH:29]=[O:30])[CH3:31].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[c:2]1([CH:29]=[O:30])[cH:3][cH:4][c:5]([CH:8]2[O:9][CH2:10][CH2:11][N:12]([CH:14]([CH3:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 755968782-(4-Bromophenyl)-4-(1-phenylethyl)morpholineHCID 178418339Butyllithium

Product 1

HCID 722548274-((S)-4-((R)-1-Phenylethyl)morpholin-2-yl)benzaldehyde

Sources & evidence

ORD record
ord-091de7990ab64c63bb1339a644f40955
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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