Tetrahydrofuran → Tert-butyl 2-(4-bromo-3-fluorophenyl)morpholine-4-carboxylate

HRID 94927Notes

Reaction equation

HRID 94927 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH2:8][CH2:9][OH:10])[CH2:11][CH:12]([OH:13])[c:14]1[cH:15][c:16]([F:21])[c:17]([Br:20])[cH:18][cH:19]1)=[O:22].[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:30][S:31](=[O:32])(=[O:33])[Cl:34]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]1[CH2:8][CH2:9][O:13][CH:12]([c:14]2[cH:15][c:16]([F:21])[c:17]([Br:20])[cH:18][cH:19]2)[CH2:11]1)=[O:22]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68325535(RS)-[2-(4-bromo-3-fluoro-phenyl)-2-hydroxy-ethyl]-(2-hydroxy-ethyl)-carbamic acid tert-butyl ester

Product 1

HCID 68325716Tert-butyl 2-(4-bromo-3-fluorophenyl)morpholine-4-carboxylate

Sources & evidence

ORD record
ord-f7d96bac638d4a82810ea1362cdaa9fd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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