Dichloromethane → N-(2-methylpropyl)-N-[(quinolin-3-yl)methyl]piperidin-4-amine

HRID 949330Notes

Reaction equation

HRID 949330 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][c:16]2[cH:17][n:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]3[cH:25]2)[CH2:26][CH:27]([CH3:28])[CH3:29])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:30][O:31][c:32]1[cH:33][cH:34][cH:35][cH:36][cH:37]1.[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][c:16]2[cH:17][n:18][c:19]3[cH:20][cH:21][cH:22][cH:23][c:24]3[cH:25]2)[CH2:26][CH:27]([CH3:28])[CH3:29])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 685745204-{Isobutyl-[(quinolin-3-yl)methyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 57640314N-(2-methylpropyl)-N-[(quinolin-3-yl)methyl]piperidin-4-amine

Sources & evidence

ORD record
ord-e0f60ffc59a74ab5ad9cf4e86b875a75
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…