Toluene → Tert-butyl 3-[(3-chlorophenyl)-hydroxy-methyl]piperidine-1-carboxylate

HRID 949370Notes

Reaction equation

HRID 949370 reaction equation
[BH3:30].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[CH3:36][CH2:37][O:38][C:39](=[O:40])[CH3:41].[Cl:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[CH:7]2[CH2:8][N:9]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:10][CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1>>[Cl:1][c:2]1[cH:3][c:4]([CH:5]([OH:6])[CH:7]2[CH2:8][N:9]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:10][CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 6331BoraneHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 53420072Tert-butyl 3-(3-chlorobenzoyl)piperidine-1-carboxylate

Product 1

HCID 58011573Tert-butyl 3-[(3-chlorophenyl)-hydroxy-methyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-757977fdd9e84041a2fa69e2a6560a36
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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