Hydrochloric Acid → ethyl 2-[[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]amino]cyclohexane-1-carboxylate

HRID 950178Notes

Reaction equation

HRID 950178 reaction equation
[CH3:18][N:19]1[CH2:20][CH2:21][N:22]([c:25]2[n:26][c:27]([NH2:41])[n:28][c:29](-[c:31]3[cH:32][cH:33][c:34]4[c:39]([cH:40]3)[CH2:38][NH:37][CH2:36][CH2:35]4)[cH:30]2)[CH2:23][CH2:24]1.[Cl:14][C:15]([Cl:16])=[O:17].[ClH:1].[ClH:42].[NH2:2][CH:3]1[CH:4]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:5][CH2:6][CH2:7][CH2:8]1>>[NH:2]([CH:3]1[CH:4]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:5][CH2:6][CH2:7][CH2:8]1)[C:15](=[O:17])[N:37]1[CH2:36][CH2:35][c:34]2[cH:33][cH:32][c:31](-[c:29]3[n:28][c:27]([NH2:41])[n:26][c:25]([N:22]4[CH2:21][CH2:20][N:19]([CH3:18])[CH2:24][CH2:23]4)[cH:30]3)[cH:40][c:39]2[CH2:38]1

Participants

5

Reactant 4

HCID 313Hydrochloric Acid2×HCID 6371PhosgeneHCID 4171533Ethyl 2-aminocyclohexanecarboxylateHCID 497794384-(4-Methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine

Product 1

HCID 59496738ethyl 2-[[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydro-1H-isoquinoline-2-carbonyl]amino]cyclohexane-1-carboxylate

Sources & evidence

ORD record
ord-9d856adbd51c4b0c961bc694d39b5e44
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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