Dichloromethane → N-(2-hydroxy-2-methylpropyl)-N-[(2,4-dichloro-1,3-thiazol-5-yl)methyl]piperidin-4-amine

HRID 950303Notes

Reaction equation

HRID 950303 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][C:16]([CH3:17])([CH3:18])[OH:19])[CH2:20][c:21]2[c:22]([Cl:27])[n:23][c:24]([Cl:26])[s:25]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:28][O:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[Cl:43][CH2:44][Cl:45].[OH:36][C:37]([C:38]([F:39])([F:40])[F:41])=[O:42]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]([CH2:15][C:16]([CH3:17])([CH3:18])[OH:19])[CH2:20][c:21]2[c:22]([Cl:27])[n:23][c:24]([Cl:26])[s:25]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 685774114-{[(2,4-Dichloro-thiazol-5-yl)methyl]-(2-hydroxy-2-methyl-propyl)-amino}-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 57640324N-(2-hydroxy-2-methylpropyl)-N-[(2,4-dichloro-1,3-thiazol-5-yl)methyl]piperidin-4-amine

Sources & evidence

ORD record
ord-93252717b9ab44e9baf1361284863a73
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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