Dimethyl Sulfoxide → 1-N-Cbz-3-pyrrolidinone

HRID 950353Notes

Reaction equation

HRID 950353 reaction equation
[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][C:19](=[O:20])[N:21]1[CH2:22][CH:23]([OH:26])[CH2:24][CH2:25]1.[CH3:1][S:2](=[O:3])[CH3:4].[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[Cl:34][CH2:35][Cl:36].[Cl:5][C:6]([C:7]([Cl:8])=[O:9])=[O:10].[OH2:37]>>[CH2:11]([c:12]1[cH:13][cH:14][cH:15][cH:16][cH:17]1)[O:18][C:19](=[O:20])[N:21]1[CH2:22][C:23](=[O:26])[CH2:24][CH2:25]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 560953Benzyl 3-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 5612031-N-Cbz-3-pyrrolidinone

Sources & evidence

ORD record
ord-c83def27c4084d8c86f5a815345eb8f3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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