Formaldehyde → 1H-Indazole-5-carboxaldehyde

HRID 950710Notes

Reaction equation

HRID 950710 reaction equation
[C:11]=[O:12].[I:1][c:2]1[cH:3][c:4]2[cH:5][n:6][nH:7][c:8]2[cH:9][cH:10]1.[O:13]=[CH:14][N:15]([CH3:16])[CH3:17].[Pd:18]([Cl:19])[Cl:20].[c:21]1([P:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1.[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[c:2]1([CH:14]=[O:13])[cH:3][c:4]2[cH:5][n:6][nH:7][c:8]2[cH:9][cH:10]1

Participants

6

Reactant 5

HCID 712FormaldehydeHCID 6228DimethylformamideHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 218947395-Iodo-1H-indazole

Product 1

HCID 212506441H-Indazole-5-carboxaldehyde

Sources & evidence

ORD record
ord-312b0d6f85014cc8af07033cffd7027f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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