Hydrochloric Acid → 1-{2-[4-(8-Methoxy-11,13-dihydro-12-oxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-11-yl)-phenoxy]-ethyl}-piperidine

HRID 950814Notes

Reaction equation

HRID 950814 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[ClH:1].[OH2:44].[OH:2][CH2:3][c:4]1[c:5](-[c:10]2[c:11]([CH:22]([OH:23])[c:24]3[cH:25][cH:26][c:27]([O:30][CH2:31][CH2:32][N:33]4[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]4)[cH:28][cH:29]3)[c:12]3[cH:13][cH:14][c:15]([O:20][CH3:21])[cH:16][c:17]3[cH:18][cH:19]2)[cH:6][cH:7][cH:8][cH:9]1>>[CH2:3]1[c:4]2[c:5]([cH:6][cH:7][cH:8][cH:9]2)-[c:10]2[c:11]([c:12]3[cH:13][cH:14][c:15]([O:20][CH3:21])[cH:16][c:17]3[cH:18][cH:19]2)[CH:22]([c:24]2[cH:25][cH:26][c:27]([O:30][CH2:31][CH2:32][N:33]3[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]3)[cH:28][cH:29]2)[O:23]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 8028TetrahydrofuranHCID 17987053[2-(2-Hydroxymethyl-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanol

Product 1

HCID 589615531-{2-[4-(8-Methoxy-11,13-dihydro-12-oxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-11-yl)-phenoxy]-ethyl}-piperidine

Sources & evidence

ORD record
ord-ada0a209f4b04669b8fab293a69f8278
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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