Potassium Cation → Ethyl 5-[(tert-butoxycarbonyl)amino]-2-(6-morpholin-4-ylpyridin-3-yl)-1,3-thiazole-4-carboxylate
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[n:11][c:12]([I:14])[s:13]1.[CH3:20][C:21]1([CH3:22])[C:23]([CH3:24])([CH3:25])[O:26][B:27]([c:28]2[cH:29][cH:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[n:32][cH:33]2)[O:40]1.[CH3:68][CH2:69][O:70][C:71](=[O:72])[CH3:73].[CH:41]1([P:42]([CH:43]2[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2)[CH:49]2[CH2:50][CH2:51][CH2:52][CH2:53][CH2:54]2)[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]1.[K+:65].[K+:66].[K+:67].[O:112]=[C:113]([CH:114]=[CH:115][c:116]1[cH:117][cH:118][cH:119][cH:120][cH:121]1)[CH:122]=[CH:123][c:124]1[cH:125][cH:126][cH:127][cH:128][cH:129]1.[O:130]1[CH2:131][CH2:132][O:133][CH2:134][CH2:135]1.[O:76]=[C:77]([CH:78]=[CH:79][c:80]1[cH:81][cH:82][cH:83][cH:84][cH:85]1)[CH:86]=[CH:87][c:88]1[cH:89][cH:90][cH:91][cH:92][cH:93]1.[O:94]=[C:95]([CH:96]=[CH:97][c:98]1[cH:99][cH:100][cH:101][cH:102][cH:103]1)[CH:104]=[CH:105][c:106]1[cH:107][cH:108][cH:109][cH:110][cH:111]1.[P:60]([O-:61])([O-:62])([O-:63])=[O:64].[Pd:74].[Pd:75]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][c:9]1[c:10]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[n:11][c:12](-[c:28]2[cH:29][cH:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[n:32][cH:33]2)[s:13]1Participants
10
Reactant 9
HCID 813Potassium Cation3×
HCID 1061Phosphate
HCID 8857Ethyl Acetate
HCID 23938Palladium2×
HCID 312751,4-Dioxane
HCID 75806Tricyclohexylphosphine
HCID 95417Dibenzylidene acetone3×
HCID 27953634-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)morpholine
HCID 67306268Ethyl 5-((tert-butoxycarbonyl)amino)-2-iodothiazole-4-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-19e5d9b54b4449f5ab7cf783f86b71eb
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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