Ammonia → 2-(1-Azetidin-3-yl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenol

HRID 951110Notes

Reaction equation

HRID 951110 reaction equation
[CH3:36][CH2:37][O:38][CH2:39][CH3:40].[Cl:41][CH2:42][Cl:43].[NH3:35].[OH2:44].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7].[OH:8][c:9]1[c:10](-[c:19]2[cH:20][cH:21][n:22][n:23]2[CH:24]2[CH2:25][N:26]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:27]2)[cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]1>>[OH:8][c:9]1[c:10](-[c:19]2[cH:20][cH:21][n:22][n:23]2[CH:24]2[CH2:25][NH:26][CH2:27]2)[cH:11][c:12]([C:15]([F:16])([F:17])[F:18])[cH:13][cH:14]1

Participants

7

Reactant 6

HCID 222AmmoniaHCID 962WaterHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 136063628tert-Butyl 3-[5-(5-trifluoromethyl-2-hydroxyphenyl)-1H-pyrazol-1-yl]azetidine-1-carboxylate

Product 1

HCID 1360636202-(1-Azetidin-3-yl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenol

Sources & evidence

ORD record
ord-d19134ed944e425bbe5c3b4ada70daab
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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